Akademik Bilgiler



ZEKİ TOPÇU
PROFESÖR
Eczacılık Fakültesi
Eczacılık Teknolojisi Bölümü
Farmasötik Biyoteknoloji Ana Bilim Dalı
İletişim Bilgileri- E-posta: zeki.topcu@ege.edu.tr
- Telefon: Ofis: (232)3111931 Lab: (232)3115133
- Web sayfası: http://www.pharm.ege.edu.tr/index.php?p=person&num=64&dep=15
Eğitim Bilgileri- Lisans: O.D.T.Ü Fen ve Edb. Fakültesi Ankara, Türkiye, 1981
- Yüksek Lisans: Cukurova Univ. Tıp Fakültesi Adana, Türkiye , 1985
- Yüksek Lisans: Hungarian Academy of Sci. Szeged, Macaristan , 1988
- Doktora: E. Virginia Medical School, Norfolk, VA, A.B.D., 1995
- Yardımcı Doçentlik: Ege Üniv. Ecz. Fakültesi İzmir, Türkiye, 1996
- Doçentlik: Ege Üniv. Ecz. Fakültesi İzmir, Türkiye, 2000
- Profesörlük: Ege Üniv. Ecz. Fakültesi İzmir, Türkiye, 2006

İdari ve Akademik Görevleri (5 adet)- E. Ü. Fen Bilimleri Enst. Biyoteknoloji Bölümü Moleküler Biyoloji Bilim Dalı Başkanı, 2008-
- E. Ü. Ecz. Fakültesi Ecz. Teknol. Bölümü Farm. Biyoteknoloji Anabilim Dalı Başkanı, 2003-
- Visiting Professor. Dept. of Genetics University of Georgia, Athens, GA, 2001-2003
- Post Doc. Dept. of Biochemistry Dalhousie University Halifax, BS: Canada, 1997-1998
- Res./Teaching Assistant. E. VA Med. Sch. Dept. of Biomed. Sci/Mol. Cell. Biol. Norfolk, VA, USA, 1991-1995
Uzmanlık Alanları- Moleküler Biyoloji (4010200)
- Moleküler Genetik (4010202)
- Biyoteknoloji (6140207)
İndekslerce Taranan Dergilerdeki Yayınları (47 adet)- Zupkó I, Molnár J, Réthy B, Minorics R, Frank E, Wölfling J, Molnár J, Ocsovszki I, Topcu Z, Bitó T, Puskás LG. (2014) Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate. Molecules. 17; 2061-2076. I.F: 2.484
- Senarisoy M, Canturk P, Zencir S, Baran Y, Topcu Z. (2013) Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks. Cell Biochem Biophys. 66(1):199-204. I.F: 3.743
- Zencir S, Ovee M, Dobson M, Monimoy B, Topcu Z and Mohanty S (2013). Identification of Brain-Specific Angiogenesis Inhibitor 2 as an Interaction Partner of Glutaminase Interacting Protein. Biochem. Biophys. Res. Commun. 411:792-797 I.F: 2.484
- Zencir S, Banerjee M, Dobson MJ, Ayaydin F, Fodor EA, Topcu Z, Mohanty S. (2013) New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP). Biochem Biophys Res Commun.432:10-15 I.F: 2.484
- Zencir S, Sike A, Dobson MJ, Ayaydin F, Boros I, Topcu Z. (2013) Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes. Biochem J. 450: 311-320. I.F: 4.897
- Sarikaya B, Zencir S; Somer N, Kaya GI, Onur, MA, Zupko I and Topcu Z (2012) The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity Rec. Nat. Products 6: 381-385
- Ozsarlak-Sozer G, Kerry Z, Gokce G, Oran I, Topcu Z (2011). Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty. J Physiol Biochem. 67: 35-42.
- Basenko E, Topcu Z and McEachern M. J. (2011). Recombination can either help maintain very short telomeres or generate longer telomeres via a roll-and-spread mechanism in yeast cells with weak telomerase activity. Eukaryot. Cell 10: 1131-1142. 3.604
- Canturk P, Caner V, Oruc N, Akarca US, Tepeli E, Cetin OG, Zencir S, and Topcu Z 2010) The mRNA Expression of Cytochrome P450 Isoforms in Human Gastric Tissue. Hepatogastroenterology 57,372-376
- Mete E, Gul HI, Canturk P, Topcu Z, Pandit B, Gul M, Li PK. (2010) Biological activity of 1-aryl-3-phenethylamino-1-propanone hydrochlorides and 3-aroyl-4-aryl-1-phenethyl-4-piperidinols on PC-3 cells and DNA topoisomerase I enzyme. Z Naturforsch C. 65: 647-652.
- Baran Y, Zencir S, Cakir Z, Ozturk E, Topcu Z (2010). Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition. J Clin Pharm Ther. 36, 673-679.
- Harris L, Debelec, B, Masologites, G, McRae W, Topcu Z and McEachern M, J. (2009) Mutant telomeric repeats can promote runaway recombinationaltelomere elongation. Mol. Cell Biol. 29: 626-39.
- Bechard LH, Butuner BD, Masologites G, McRae W, Topcu Z, McEachern MJ. Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an ALT-like phenotype. Mol Cell Biol. 29:626-39, 2009
- Ozsarlak-Sozer G, Kerry Z, Oran, I.Gokce G, Tosun M, Bechard L, Reel B, Yasa M, Lebe B and Topcu Z (2009). Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits J Physiol Biochem 65, 243-249.
- Alptekin D Ozturk E , Izmirli M , Zencir S , Bayazit Y , and Topcu (2009) Interindividual Difference in CYP2A6 Genotypes as Determined with Restrictional Fragment Length Polymorphism in Relation to GSTM1 and GSTT1 Genes Among the Patients with Prostate
- 2009, Coban G, Zencir S, Zupkó I, Réthy B, Gunes HS, and Topcu Z (2008) Synthesis and Biological Activity Evaluation of 1H-Benzimidazoles via Mammalian DNA Topoisomerase I and Cytostaticity Assays. Eur. J. Med. Chem. 2008 Jun 26. [Epub ahead of print].
- Emre M, Cetiner S, Zencir S and Topcu Z (2009). Apoptotic and Necrotic Cell Percentages in Kidney Cells from Rats Exposed to Magnetic Field Drug Metab Rev 41, 38-30.
- Topcu Z, Ozturk B, Kucukoglu O, and Kilic E (2008) Inhibition of mammalian type I DNA topoisomerase by Helichrysum pamphylicum is correlated with the total antioxidant capacities of its individual flavonoids. Z. Naturforsch., C, J. Biosci. 63, 69-74.
- Gul HI, Cizmecioglu M, Zencir S, Gul M, Canturk P, Atalay M, and Topcu Z (2008) Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I. J. Enzyme Inh. Med Chem. 2008 Oct 1:1. [Epub a
- Zencir S, Alptekin D, Celiktas M, Canturk P, Colak D, Caner V, Luleyap UH, and Topcu Z (2008) Detection of Cytochrome P450-2A6, -3A5 and -4B1 with Real-Time Polymerase Chain Reaction in Prostate Tissue. Naturforsch., C, J. Biosci. (2008). 780-4.
- Canturk P, Kucukpglu K, Topcu Z, Gul M, and Gul I (2008). Effect of some bis-mannich bases and corresponding piperidinols on DNA topoisomerse I. Arzneimittel Forsch. 2008, 58, 686-691.
- Alpan S, Zencir S, Zupkó I, Coban C, Réthy B, Gunes HS, and Topcu Z (2008) Biological Activity of Bis-benzimidazole Derivatives on DNA Topoisomerase I and HeLa, MCF7 and A431 Cells. J Enzyme Inhib Med Chem. 2008 Oct 27:1. [Epub ahead of print].
- Sarikaya D, Chiba I, Bilgen C, Kamataki T, and Topcu Z (2007) RT-PCR-Based Cytochrome P450 expression profile of Oral Tissue Samples. J. Clin. Pharm. Ther. 32, 445-448.
- Alpan S, Gunes S, and Topcu Z (2007) 1H-Benzimidazole Derivatives as Mammalian DNA Topoisomerase I Inhibitors. Acta Biochim. Pol. 54, 561-565.
- Sarikaya D, Bilgen C, Kamataki T, and Topcu Z (2006) Comparative Cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue. Biopharm. Drug Dispos. 27, 353-359.
- Kucukoglu O, Ozturk B, Kamataki T, and Topcu Z (2006) Inhibitory activities of Helichrysum taxa on mammalian type I DNA Topoisomerase. Pharm. Biol. 44, 189-193.
- Kocadag E, Sarıkaya D, Telefoncu A, and Topçu Z. "Effects of nick formation on DNA substrates via UV-irradiation on the kinetic parameters of mammalian DNA topoisomerase I". FEBS J, 273 (1), pp 188, 2006.
- Gumus SN, Lermioglu F, Goksel T Kamataki T, Fujieda M, Topcu, Z. Inter-individual variation of GSTM1 and GSTT1 genotypes in relation to lung cancer risk among habitual tobacco smokers in Turkey FEBS J 273, 260-261, 2006.
- Zencir S, Gumus NS, Lermioglu F, Kilic F, Goksel T, Fujieda M, Kamataki T, Topcu, Z. Inter-individual variation in CYP2A6 genotypes in relation to lung cancer risk among habitual tobacco smokers in Turkey FEBS J 273, 260-260, 2006.
- Kucukoglu O, Ozturk B, Kamataki T, and Topcu Z (2006) Inhibitory activities of Helichrysum taxa on mammalian type I DNA Topoisomerase. Pharm. Biol. 44, 189-193
- Topcu Z, Kucukoglu O, Ozturk B, and Kamataki T. "Inhibitory activities of the endemic Helichrysum". Drug Met. Rev. 37(2), pp 373, 2005.
- Ozsarlak Sozer G, Kerry Z, Oran I, Gokce G, McEachern MJ, and Topcu Z. "Telomere length regulation in the proliferation of vascular smooth muscle cells". FEBS J. 272 (1), pp 129, 2005.
- Topcu Z, Nickles K, Davis C, and McEachern M (2005) Abrupt disruption of capping and a single source for recombinationally elongated telomeres in K. lactis. Proc. Natl. Acad. Sci. (USA) 102, 3348-3353.
- Sarikaya D, Chiba I, Bilgen C, Altan G, Güneri P, Masaki F, Kamataki T and Topcu Z. Comparative Cytochrome P450-2C, -2E1, -3A5 and -2A6 expression in oral tissue samples of the individuals with habitual tobacco smokers. FEBS J. 272 (1). 136, 2005.
- Topcu Z, Nickles K, Davis C McEachern MJ A single source for recombinationally elongated telomeres in K-lactis FEBS J 272 (1), 568, 2005.
- Topcu Z, Chiba I, Fujieda M, Shibata T, Ariyoshi N, Yamazaki H, Sevgican F, Muthumala M, Kobayashi H, and Kamataki T (2002) CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. Carcinogenesis 23, 595-598.
- Topcu Z, Chiba I, Fujieda M. "The relationship between CYP2A6 gene deletion and susceptibility to oral cancer". Drug Metab. Rev. 34: 307 Suppl. 1 2002
- Topcu Z. An indirect lectin-affinity bioassay for Uromodulin. T. J. Biochem. 26, 363-367, 2002.
- Topcu Z (2001) DNA topoisomerases as targets for anticancer drugs. J. Clin. Pharm. Ther. 26, 405-416.
- Topcu Z (2000) An optimized recipe for cloning of the polymerase chain reaction-amplified DNA inserts into plasmid vectors. Acta Biochim. Pol. 47, 841-846.
- Topcu Z (2000) Densitometric quantification of DNA topoisomers in ethidium bromide-stained agarose gels and chemiluminescence-detected X ray films. Acta Biochim. Pol. 47, 835-839.
- Topcu Z and Borden KL (2000) The yeast two-hybrid system and its pharmaceutical significance. Pharm. Res. 17, 1049-1055.
- Topcu Z, Mack DL, Hromas RA and Borden KL (1999) The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene 18, 7091-7100.
- 1999, Borden KL, Topcu Z, and Lai HK The promyelocytic leukemia protein PML associates with hematopoietically expressed homeodomain protein PRH: Implications for a role for PML in myeloid cell development. Blood 92, 863.
- Topcu Z and Castora FJ (1995) Mammalian mitochondrial DNA topoisomerase I preferentially relaxes supercoils in plasmids containing specific mitochondrial DNA sequences. Biophys. Biochim. Acta. 1264, 377-387.
- Topcu Z, and Castora FJ. "Kinetic characterization of mammalian mitochondrial DNA topoisomerase I." FASEB J. 8(7). 784, 1994.
- Ciavarra RP, Goldman C, Topcu Z, and Castora FJ."Heat shock cognate protein 70 protects type I topoisomerase activity from thermal inactivation". J. Cell. Biol. 115, 255, 1992.

Uluslararası Toplantılarda Sunulan Bildirileri (37 adet)- Ozturk, E.; Sukatar, A.; Topcu, Z. Investigation of the expression of light dependency of a Chlamyopsin family gene, COP5, in Chlamydomonas reinhardii FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 146-146 Published: JUN 2011
- Canturk P, Senarisoy M, Nitiss J and Topcu Z (2011). Effects of Gefitinib in the sensitivity of selected Saccharomyces cerevisiae strains FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 324-324 Published: JUN 2011
- Topcu, Zeki; 2011 Selected compounds that interfere with the catalytic cycles of type I and type II DNA topoisomerases DRUG METABOLISM REVIEWS Volume: 43, Supplement: 1, Pages: 51-51.
- Zencir S, Baros I, Dobson M and Zeki Topcu (2011) Identification of new potential interaction partners of human ADA3 via yeast hybrid technology FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 82-83 Published: JUN 2011
- 2010, Canturk P., Istanbullu H., Zencir S., Erciyas E., Zupko I., Topcu Z., "The Interference of Piperidinopropionaphtone hydrochloride in DNA Topoisomerase Reactions," 16th North American Regional International Society for the Study of Xenobiotics Meeting,
- Topcu Z., Koizumi F., Unlukurt I. Zencir S.,, "Effect of Iressa on the reactions of mammalian type I and type II DNA topoisomerases." 101st. American Association of Cancer Research (AACR-2010), Washingthon, Nisan 2010
- 2009, Emre M, Cetiner S, Zencir S, Topcu Z. Apoptotic and Necrotic Cell Percentages in Kidney Cells from Rats Exposed to Magnetic Field DRUG METABOLISM REVIEWS Volume: 41 Pages: 38-38
- 2009, Alptekin D, Ozturk E, Izmirli M, Zencir S, Bayazit Y, Topcu Z Interindividual Difference in CYP2A6 Genotypes as Determined with Restrictional Fragment Length Polymorphism in Relation to GSTM1 and GSTT1 Genes Among the Patients with Prostate Carcinoma. DRUG METABOLISM REVIEWS Volume: 41 Pages: 30-30
- 2008, Zencir S, Coban G, Zupko I, Rethy B, Gunes HS, and Topcu Z. ‘Synthesis and Biologic Activity of 1H-Benzimidazoles via Mammalian DNA Topoisomerase I and Cytotoxicity Assays’ 3. AACR International Conferance on Molecular Diagnostics in Cancer Therapeutic D
- 2008, Topcu Z, Cizmecioglu M, Zencir S, Gul M, Canturk P, Atalay M, Gul HI. ‘Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I’ 3. AACR International Conferance on Molecular Diagnostics
- Ozsarlak-Sozer, G.; Gokce, G.; Oran, I. Topcu, Z. TELOMERE LENGTH REGULATION OF VASCULAR SMOOTH MUSCLE CELLS IN A BALLOON INJURY MODEL: EFFECTS OF OXIDATIVE STRESSATHEROSCLEROSIS SUPPLEMENTS Volume: 9 Issue: 1 Pages: 56-57 DOI: 10.1016/S1567-5688(08)70222-8 Published: MAY 2008
- Zencir S, Alpan S, Gunes HS, and Topcu Z. ‘Synthesis and Kinetic Evaluation of 1H-Benzimidazole as Mammalian DNA Topoisomerase I Inhibitor’ 8th International ISSX Meeting 9–12 October, 2007 Sendai, Japan.
- Zencir S, Alptekin D, Celiktas M, Colak D, Luleyap UH and Topcu Z. ‘Expression of Cytochrome P450-2A6, -3A5 and -4B1 at mRNA Level in Prostate Tissue’ 8th International ISSX Meeting 9–12 October, 2007 Sendai, Japan.
- Topcu Z and Canturk P. ‘DNA Topoisomerases as the Targets of Anti-Cancer Drugs’ European Conference on Cancer and Ageing, 4-6 October, 2007 Warsaw, Poland.
- Canturk P, Akarca US, Oruc N, Zencir S and Topcu Z. ‘Determination of Cytochrome P450 Isoforms Expressed in Stomach Tissue Samples’ European Conference on Cancer and Ageing, 4-6 October, 2007 Warsaw, Poland.
- Zencir, Sevil; Alptekin, Davut; Celiktas, Medih; Colak, D (Colak, Deniz)[ 2 ] ; Luleyap, UH (Luleyap, Umit H.)[ 2 ] ; Topcu, Z EXPRESSION OF CYTOCHROME P450-2A6,-3A5 AND-4B1 IN PROSTATE TISSUEDRUG METABOLISM REVIEWS Volume: 39 Supplement: 1 Pages: 193-193 Meeting Abstract: 271 Published: 2007
- Zencir, Sevil; Alptekin, Davut; Celiktas, Medih; Colak, D (Colak, Deniz)[ 2 ] ; Luleyap, UH (Luleyap, Umit H.)[ 2 ] ; Topcu, Z. EXPRESSION OF CYTOCHROME P450-2A6,-3A5 AND-4B1 IN PROSTATE TISSUEDRUG METABOLISM REVIEWS Volume: 39 Supplement: 1 Pages: 193-193 Meeting Abstract: 271 Published: 2007
- Soyer Z, Koacadağ E, Pabuccuoğlu V, Telefoncu A & Topçu Z. "Inhibitory activities of benzoaxol derivatives on mammalian type I DNA topoisomerase". FEBS J, 273 (1), pp 193, 2006.
- Kocadag, E.; Sarikaya, D.; Telefoncu, A,; Topcu, Z. Effects of nick formation on DNA substrates via UV-irradiation on the kinetic parameters of mammalian DNA topoisomerase I FEBS JOURNAL Volume: 273 Supplement: 1 Pages: 188-189, Meeting Abstract: PP415, Published: JUN 2006
- Soyer, Z.; Kocadag, E.; Pabuccuoglu, V Telefoncu, A (Telefoncu, A.); Topcu, Z Inhibitory activities of benzoaxol derivatives on mammalian type I DNA topoisomerase FEBS JOURNAL Volume: 273 Supplement: 1 Pages: 193-194 Meeting Abstract: PP434 Published: JUN 2006
- Gumus, S. N.; Lermioglu, F.; Goksel, T Kamataki, T (Kamataki, T.); Fujieda, M (Fujieda, M.); Topcu, Z; Inter-individual variation of GSTM1 and GSTT1 genotypes in relation to lung cancer risk among habitual tobacco smokers in Turkey FEBS JOURNAL Volume: 273 Supplement: 1 Pages: 260-261 Meeting Abstract: PP680 Published: JUN 2006
- Topcu Z, Kucukoglu O, Ozturk B, and Kamataki T. "Inhibitory activities of the endemic Helichrysum". Drug Met. Rev. 37(2), pp 373, 2005.
- Debelec B, Kantarcı G, McRae W, McEachern MJ, and Topcu Z. "Recombinational telomere elongation in telomerase deletion mutant of Kluveromyces lactis". FEBS J. 272 (1), pp 545, 2005.
- Iyer S, Groff-Vindman C, Cesare AJ, Topcu Z, Natarajan S, Basenko E, Harris L, Griffith JD, and McEachern MJ. "Mechanisms of recombinational telomere elongation in the yeast K. lactis". FASEB Genetic Recombination Conference, Snowmass, CO, July, 2005
- Sozer, GO; Kerry, Z; Oran, I; Gokce, G (Gokce, G); McEachern, MJ (McEachern, MJ); Topcu, Z (Topcu, Z); Telomere length regulation in the proliferation of vascular smooth muscle cells FEBS JOURNAL Volume: 272 Supplement: 1 Pages: 129-129 Published: JUL 2005
- Kucukoglu O., Ozturk B., Zeybek U., Fujieda, M., Kamataki T. and Topcu Z. Inhibitory activities of Helichrysum taxa on mammalian type I DNA topoisomerase 30th FEBS Congress-9 th IUBMB Conference Budapest, Hungary, 2-7 July 2005.
- Topcu Z, Iyer S, and McEachern MJ. "Single telomere source for K. lactis survivor formation. EMBO Workshop/58th Harden Conference, Telomeres and Genome Stability". Robinson College, Cambridge, UK, April 3-7, 2004.
- Topcu Z, Nickles K, Davis C, and McEachern MJ. "Evidence for an abrupt loss of capping during telomere shortening in a telomerase deletion mutant. Yeast Chromosome Structure Replication and Segregation". FASEB Res. Conf. July 2004, Pine Mountain, GA
- Topcu Z, Groff-Vindman C, Iyer S, Natarajan S, and McEachern M J. "Evidence Supporting the Roll and Spread Model of Recombinational Telomere Elongation". FASEB Genetic recombination and chromosome rearrangements conference, Snowmass, CO, July 2003
- McEachern MJ, Natarajan S, Topcu Z., and Iyer S. "Mechanisms contributing to recombinational telomere elongation in K. lactis. Yeast chromosome structure, replication and segregation". FASEB conference, Snowmass, CO. June 28-July 1, 2002.
- Yamazaki H., Fujieda M., Chiba I., Topcu Z., et al. Genetic polymorphism of CYP2A6 and cancer risk 14th Intrnational Symposium on Microsoms and D rug Oxidations (MDO2002), July 22-26, Sapporo Japan
- Topcu Z, Natarajan S, Nickles K, and McEachern MJ. "Elongated telomeres of K. lactis post-senescence survivors commonly arise from a single telomere source. AACR San Francisco, CA, December 7-11, 2002
- Yamazaki H, Chiba I.,Topcu Z., et al.CYP2A6 gene deletion reduces cancer risk in betel quid chewers. 14th Intrnational Symposium on Microsomes and Drug Oxidations (MDO2002), July 22-26, Sapporo Japan
- Topcu Z, Chiba I, Fujieda M (2002) The relationship between CYP2A6 gene deletion and susceptibility to oral cancer. Drug Met Rev: 34, 307.
- Lestienne P, Mareau S, Lemoine S, Jourdren I, Montaillet S, Topcu Z "Construction of Rec A gene for destination into mitochondria". Colloque des 3R meeting, June 3,1997 Villejuif, France
- Topcu, Z., and Castora, F. J.(1993) "Kinetic characterization of mammalian mitochondrial FNA topoisomerase I EVMS Research Days, Norfolk, VA, USA
- 0,

Ulusal Toplantılarda Sunulan Bildirileri (4 adet)- Topcu, Z. A novel strategy for development of DNA topoisomerase-targeting anticancer drugs using a modified yeast-two-hybrid system. 10thInternational Pharmacutical Technology symposium .Sept 11-13, 2000. İstanbul
- Topcu Z., and Borden, K. L. Proline-rich homeobox protein (PRH) as an interacting partner of Z protein of Arenavirus and promyelocytic leukemia protein (PML). The First Internationl Biosciences days, April 20-24, 1999. Antalya.
- Topcu, Z. Maya iki hibrit sisteminin Eczacılık alnındaki uygulamları 6. Ulusararası katılımlı Biyomedikal Bilim ve teknoloji sempozyumu 06-08 Ekim, 1999. İzmir.
- Topcu, Z. Rekombinant DNA teknolojisinin temel prensipleri.XII. Ulusal Biyokimya Kongresi. 26-30 Mart, 1996. Antalya. Çağrılı konuşmacı olarak katılmıştır.

Kaynak Gösterilme AdetleriKendisi tarafından 70 kez kaynak gösterilmiştir.
Başkaları tarafından 277 kez kaynak gösterilmiştir.
İndeksli Yayınlarını Kaynak Gösteren Yayınlar (316 adet)- 2014, Zilifdar, Fatma; Alper-Hayta, Sabiha; Yilmaz, Serap; et al. Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives, MEDICINAL CHEMISTRY RESEARCH Volume: 23 Issue: 1 Pages: 480-486 Published: JAN 2014
- 2013, Chan, Mooi Kwai; Fadzil, Nur Adila; Chew, Ai Lan; et al. New molecular biologist perspective and insight: DNA topoisomerases production by recombinant DNA technology for medical laboratory application and pharmaceutical industry. ELECTRONIC JOURNAL OF BIOTECHNOLOGY Volume: 16 Issue: 6 Article Number: 6 Published: NOV 15 2013
- 2013, Janockova, Jana; Gulasova, Zuzana; Musilek, Kamil; et al. Novel cholinesterase modulators and their ability to interact with DNA. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY Volume: 115 Pages: 364-369 Published: NOV 2013
- 2013, Li Yaoyao; Shen Yuemao, Chemical Components of Some Microorganisms Isolated from Specific Habitats and Their Antitumor Activities. CHINESE JOURNAL OF ORGANIC CHEMISTRY Volume: 33 Issue: 6 Pages: 1135-1143 Published: JUN 2013
- 2013, Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks, CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, Pogorelnik, Barbara; Perdih, Andrej; Solmajer, Tom. Recent Developments of DNA Poisons - Human DNA Topoisomerase II alpha Inhibitors - as Anticancer Agents. CURRENT PHARMACEUTICAL DESIGN Volume: 19 Issue: 13 Pages: 2474-2488 Published: APR 2013
- 2013, Ferreira, Ruben; Artali, Roberto; Benoit, Adam; et al. Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines. PLOS ONE Volume: 8 Issue: 3 Article Number: e57701 Published: MAR 15 2013
- 2013, Pogorelcnik, B.; Perdih, A.; Solmajer, T. Recent Advances in the Development of Catalytic Inhibitors of Human DNA Topoisomerase II alpha As Novel Anticancer Agents. CURRENT MEDICINAL CHEMISTRY Volume: 20 Issue: 5 Pages: 694-709 Published: FEB 2013
- 2013, Targeting of Arenavirus RNA Synthesis by a Carboxamide-Derivatized Aromatic Disulfide with Virucidal Activity By: Sepulveda, Claudia S.; Garcia, Cybele C.; Levingston Macleod, Jesica M.; et al. PLOS ONE Volume: 8 Issue: 11 Article Number: e81251 Published: NOV 20 2013
- 2013, Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes By: Zencir, Sevil; Sike, Adam; Dobson, Melanie J.; et al. BIOCHEMICAL JOURNAL Volume: 450 Pages: 311-320 Part: 2 Published: MAR 1 2013
- 2013, Cytochrome P450 Metabolism of Betel Quid-Derived Compounds: Implications for the Development of Prevention Strategies for Oral and Pharyngeal Cancers By: Lin, Che-Yi; Pan, Tien-Szu; Ting, Chun-Chan; et al. SCIENTIFIC WORLD JOURNAL Article Number: 618032 Published: 2013
- 2013, Conjugation of Benzylvanillin and Benzimidazole Structure Improves DNA Binding with Enhanced Antileukemic Properties By: Al-Mudaris, Zena A.; Majid, Aman S. A.; Ji, Dan; et al. PLOS ONE Volume: 8 Issue: 11 Article Number: e80983 Published: NOV 15 2013
- 2013, Discovery of indeno[1,2-c]quinoline derivatives as dual topoisomerases I/II inhibitors: Part 3 By: Tseng, Chih-Hua; Tzeng, Cherng-Chyi; Yang, Chiao-Li; et al. MOLECULAR DIVERSITY Volume: 17 Issue: 4 Pages: 781-799 Published: NOV 2013
- 2013, Benzimidazole: a promising pharmacophore By: Shah, Kamal; Chhabra, Sumit; Shrivastava, Sushant K.; et al. MEDICINAL CHEMISTRY RESEARCH Volume: 22 Issue: 11 Pages: 5077-5104 Published: NOV 2013
- 2013, NEW BENZIMIDAZOLE DERIVATIVES AS TOPOISOMERASE I INHIBITORS - SYNTHESIS AND FLUOROMETRIC ANALYSIS By: Blaszczak-Swiatkiewicz, Katarzyna; Mikiciuk-Olasik, Elzbieta ACTA POLONIAE PHARMACEUTICA Volume: 70 Issue: 3 Pages: 451-458 Published: MAY-JUN 2013
- 2013, Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks By: Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, Antiproliferative activity of new benzimidazole derivatives By: Blaszczak-Swiatkiewicz, Katarzyna; Olszewska, Paulina; Mikiciuk-Olasik, Elzbieta ACTA BIOCHIMICA POLONICA Volume: 60 Issue: 3 Pages: 427-433 Published: 2013
- 2013, Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors By: Alpan, Ayse Selcen; Parlar, Sulunay; Carlino, Luca; et al. BIOORGANIC & MEDICINAL CHEMISTRY Volume: 21 Issue: 17 Pages: 4928-4937 Published: SEP 1 2013
- 2013, NEW BENZIMIDAZOLE DERIVATIVES AS TOPOISOMERASE I INHIBITORS - SYNTHESIS AND FLUOROMETRIC ANALYSIS By: Blaszczak-Swiatkiewicz, Katarzyna; Mikiciuk-Olasik, Elzbieta ACTA POLONIAE PHARMACEUTICA Volume: 70 Issue: 3 Pages: 451-458 Published: MAY-JUN 2013
- 2013, Synthesis of new heterocyclic compounds containing benzimidazole moiety as inhibitors of breast cancer cell growth By: Tantawy, Atif; Barghash, Alaa-eldin; Badr, Sahar; et al. HETEROCYCLIC COMMUNICATIONS Volume: 19 Issue: 2 Pages: 125-131 Published: APR 2013
- 2013, Benzimidazole Derivatives as Potential Anticancer Agents By: El Rashedy, Ahmed A.; Aboul-Enein, Hassan Y. MINI-REVIEWS IN MEDICINAL CHEMISTRY Volume: 13 Issue: 3 Pages: 399-407 Published: MAR 2013
- 2013, Antiproliferative activity of new benzimidazole derivatives By: Blaszczak-Swiatkiewicz, Katarzyna; Olszewska, Paulina; Mikiciuk-Olasik, Elzbieta ACTA BIOCHIMICA POLONICA Volume: 60 Issue: 3 Pages: 427-433 Published: 2013
- 2013, Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes By: Zencir, Sevil; Sike, Adam; Dobson, Melanie J.; et al. BIOCHEMICAL JOURNAL Volume: 450 Pages: 311-320 Part: 2 Published: MAR 1 2013
- 2013, Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks By: Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, NEW BENZIMIDAZOLE DERIVATIVES AS TOPOISOMERASE I INHIBITORS - SYNTHESIS AND FLUOROMETRIC ANALYSIS By: Blaszczak-Swiatkiewicz, Katarzyna; Mikiciuk-Olasik, Elzbieta ACTA POLONIAE PHARMACEUTICA Volume: 70 Issue: 3 Pages: 451-458 Published: MAY-JUN 2013
- 2013, Antiproliferative activity of new benzimidazole derivatives By: Blaszczak-Swiatkiewicz, Katarzyna; Olszewska, Paulina; Mikiciuk-Olasik, Elzbieta ACTA BIOCHIMICA POLONICA Volume: 60 Issue: 3 Pages: 427-433 Published: 2013
- 2013, Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks By: Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, Flavonoids as prospective compounds for anti-cancer therapy By: Ravishankar, Divyashree; Rajora, Amit Kumar; Greco, Francesca; et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY Volume: 45 Issue: 12 Pages: 2821-2831 Published: DEC 2013
- 2013, Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences By: Burrack, Laura S.; Clancey, Shelly E. Applen; Chacon, Jeremy M.; et al. MOLECULAR BIOLOGY OF THE CELL Volume: 24 Issue: 18 Pages: 2807-2819 Published: SEP 15 2013
- 2013, Plasma and Cerebrospinal Proteomes From Children With Cerebral Malaria Differ From Those of Children With Other Encephalopathies By: Gitau, Evelyn N.; Kokwaro, Gilbert O.; Karanja, Henry; et al. JOURNAL OF INFECTIOUS DISEASES Volume: 208 Issue: 9 Pages: 1494-1503 Published: NOV 1 2013
- 2013, Sticky Signaling-Adhesion Class G Protein-Coupled Receptors Take the Stage By: Langenhan, Tobias; Aust, Gabriela; Hamann, Jorg SCIENCE SIGNALING Volume: 6 Issue: 276 Article Number: re3 Published: MAY 21 2013
- 2013, New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP) By: Zencir, Sevil; Banerjee, Monimoy; Dobson, Melanie J.; et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 432 Issue: 1 Pages: 10-15 Published: MAR 1 2013
- 2013, Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes By: Zencir, Sevil; Sike, Adam; Dobson, Melanie J.; et al. BIOCHEMICAL JOURNAL Volume: 450 Pages: 311-320 Part: 2 Published: MAR 1 2013
- 2013, Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice By: Han, Miaojun; Wang, Hailun; Zhang, Hua-Tang; et al. CANCER LETTERS Volume: 328 Issue: 1 Pages: 55-64 Published: JAN 1 2013
- 2013, Effects of Prenatal and Postnatal Exposure to GSM-Like Radiofrequency on Blood Chemistry and Oxidative Stress in Infant Rabbits, an Experimental Study By: Ozgur, Elcin; Kismali, Gorkem; Guler, Goknur; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 67 Issue: 2 Special Issue: SI Pages: 743-751 Published: NOV 2013
- 2013, The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure By: Duan, Yuqing; Wang, Zhigao; Zhang, Haihui; et al. FOOD & FUNCTION Volume: 4 Issue: 8 Pages: 1252-1262 Published: AUG 2013
- 2013, Electromagnetic pulse reduces free radical generation in rat liver mitochondria in vitro By: Wang, C.; Zhou, H.; Peng, R.; et al. FREE RADICAL RESEARCH Volume: 47 Issue: 4 Pages: 276-282 Published: APR 2013
- 2013, Effects of extremely low frequency electromagnetic field on the health of workers in automotive industry By: Liu, Xin; Zhao, Longyu; Yu, Duo; et al. ELECTROMAGNETIC BIOLOGY AND MEDICINE Volume: 32 Issue: 4 Pages: 551-559 Published: 2013
- 2013, Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NO/ONOO- By: Ma, Sai; Zhang, Zhengxun; Yi, Fu; et al. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY Article Number: UNSP 529173 Published: 2013
- 2013, Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart By: Sevin, Gulnur; Ozsarlak-Sozer, Gonen; Keles, Didem; et al. EUROPEAN JOURNAL OF PHARMACOLOGY Volume: 706 Issue: 1-3 Pages: 98-106 Published: APR 15 2013
- 2013, Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis By: Matic, Ivana Z.; Aljancic, Ivana; Vajs, Vlatka; et al. NATURAL PRODUCT COMMUNICATIONS Volume: 8 Issue: 9 Pages: 1291-1296 Published: SEP 2013
- 2013, Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks By: Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii By: Matic, Ivana Z.; Aljancic, Ivana; Zizak, Zeljko; et al. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE Volume: 13 Article Number: 36 Published: FEB 18 2013
- 2013, Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks By: Senarisoy, Muge; Canturk, Pakize; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 66 Issue: 1 Pages: 199-204 Published: MAY 2013
- 2013, 1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: A novel group of tumour-selective cytotoxins By: Bilginer, Sinan; Gul, Halise Inci; Mete, Ebru; et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Volume: 28 Issue: 5 Pages: 974-980 Published: OCT 2013
- 2013, Telomere Shortening and Alzheimer's Disease By: Cai, Zhiyou; Yan, Liang-Jun; Ratka, Anna NEUROMOLECULAR MEDICINE Volume: 15 Issue: 1 Pages: 25-48 Published: MAR 2013
- 2013, Helicobacter pylori infection and antioxidants can modulate the genotoxic effects of heterocyclic amines in gastric mucosa cells By: Poplawski, Tomasz; Chojnacki, Cezary; Czubatka, Anna; et al. MOLECULAR BIOLOGY REPORTS Volume: 40 Issue: 8 Pages: 5205-5212 Published: AUG 2013
- 2013, Attenuating Effect of Gossypol on Tumor Growth in Systemic Malignancies By: Kapoor, Shailendra CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 67 Issue: 3 Pages: 1551-1552 Published: DEC 2013
- 2013, Amaryllidaceae and Sceletium alkaloids By: Jin, Zhong NATURAL PRODUCT REPORTS Volume: 30 Issue: 6 Pages: 849-868 Published: 2013
- 2012, Maheswari, Shanmugavel Uma; Perumal, Subbu. A facile sequential three-component regio- and stereoselective synthesis of novel spiro-isoxazoline/acridinone hybrids. TETRAHEDRON LETTERS Volume: 53 Issue: 51 Pages: 6885-6888 Published: DEC 19 2012
- 2012, Plsikova, Jana; Janovec, Ladislav; Koval, Jan; et al. 3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 57 Pages: 283-295 Published: NOV 2012
- 2012, Thapa, Pritam; Lee, Eung-Seok, 2,4-Diaryl-5H-chromeno [4,3-b]pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity. BULLETIN OF THE KOREAN CHEMICAL SOCIETY Volume: 33 Issue: 9 Pages: 3103-3106 Published: SEP 20 2012
- 2012, Bertucci Barbosa, Luiz Carlos; Garrido, Saulo Santesso; Garcia, Anderson; et al. Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 54 Pages: 591-596 Published: AUG 2012
- 2012, Ferreira, Ruben; Avino, Anna; Mazzini, Stefania; et al. Synthesis, DNA-Binding and Antiproliferative Properties of Acridine and 5-Methylacridine Derivatives. MOLECULES Volume: 17 Issue: 6 Pages: 7067-7082 Published: JUN 2012
- 2012, Li, Zhengguang; Li, Xingyi; Cao, Zhixing; et al. Camptothecin nanocolloids based on N,N,N-trimethyl chitosan: Efficient suppression of growth of multiple myeloma in a murine model. ONCOLOGY REPORTS Volume: 27 Issue: 4 Pages: 1035-1040 Published: APR 2012
- 2012, Yang, Zhaoqi; Li, Dawei; Guo, Juanjuan; et al. Intrinsic curvature in duplex DNA inhibits Human Topoisomerase I. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 22 Issue: 3 Pages: 1322-1325 Published: FEB 1 2012
- 2012, Khuntawee, Wasmee; Rungrotmongkol, Thanyada; Hannongbua, Supot. Molecular Dynamic Behavior and Binding Affinity of Flavonoid Analogues to the Cyclin Dependent Kinase 6/cyclin D Complex. JOURNAL OF CHEMICAL INFORMATION AND MODELING Volume: 52 Issue: 1 Pages: 76-83 Published: JAN 2012
- 2012, A Systems Biology Starter Kit for Arenaviruses By: Droniou-Bonzom, Magali E.; Cannon, Paula M. VIRUSES-BASEL Volume: 4 Issue: 12 Pages: 3625-3646 Published: DEC 2012
- 2012, Multifunctional Nature of the Arenavirus RING Finger Protein Z By: Fehling, Sarah Katharina; Lennartz, Frank; Strecker, Thomas VIRUSES-BASEL Volume: 4 Issue: 11 Pages: 2973-3011 Published: NOV 2012
- 2012, Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival By: Noy, Peter; Sawasdichai, Anyaporn; Jayaraman, Padma-Sheela; et al. NUCLEIC ACIDS RESEARCH Volume: 40 Issue: 18 Pages: 9008-9020 Published: OCT 2012
- 2012, Uncovering Viral Protein-Protein Interactions and their Role in Arenavirus Life Cycle By: Eugenia Loureiro, Maria; D'Antuono, Alejandra; Macleod, Jesica M. Levingston; et al. VIRUSES-BASEL Volume: 4 Issue: 9 Pages: 1651-1667 Published: SEP 2012
- 2012, Polymorphism of angiotensin I-converting enzyme gene is related to oral cancer and lymph node metastasis in male betel quid chewers By: Liu, Yi-Tien; Lin, Li-Wen; Chen, Chih-Yu; et al. ORAL ONCOLOGY Volume: 48 Issue: 12 Pages: 1257-1262 Published: DEC 2012
- 2012, PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6 By: McDonagh, Ellen M.; Wassenaar, Catherine; David, Sean P.; et al. PHARMACOGENETICS AND GENOMICS Volume: 22 Issue: 9 Pages: 695-708 Published: SEP 2012
- 2012, Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective By: Sharan, Rajeshwar N.; Mehrotra, Ravi; Choudhury, Yashmin; et al. PLOS ONE Volume: 7 Issue: 8 Article Number: e42759 Published: AUG 13 2012
- 2012, Application of the buccal micronucleus cytome assay and analysis of PON1Gln192Arg and CYP2A6*9(-48T > G) polymorphisms in tobacco farmers By: Da Silva, Fernanda Rabaioli; Da Silva, Juliana; Nunes, Emilene; et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS Volume: 53 Issue: 7 Pages: 525-534 Published: AUG 2012
- 2012, Role of cytochrome P-450 genetic polymorphisms in oral carcinogenesis By: Hernando-Rodriguez, Miriam; Rey-Barja, Natalia; Marichalar-Mendia, Xabier; et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE Volume: 41 Issue: 1 Pages: 1-8 Published: JAN 2012
- 2012, Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling By: Xu, Jianing; McEachern, Michael J. PLOS GENETICS Volume: 8 Issue: 11 Article Number: e1003017 Published: NOV 2012
- 2012, Maintenance of Very Long Telomeres by Recombination in the Kluyveromyces lactis stn1-M1 Mutant Involves Extreme Telomeric Turnover, Telomeric Circles, and Concerted Telomeric Amplification By: Xu, Jianing; McEachern, Michael J. MOLECULAR AND CELLULAR BIOLOGY Volume: 32 Issue: 15 Pages: 2992-3008 Published: AUG 2012
- 2012, The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity By: Sarikaya, Buket Bozkurt; Zencir, Sevil; Somer, Nehir Unver; et al. RECORDS OF NATURAL PRODUCTS Volume: 6 Issue: 4 Pages: 381-385 Published: 2012
- 2012, Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells By: Conomos, Dimitri; Stutz, Michael D.; Hills, Mark; et al. JOURNAL OF CELL BIOLOGY Volume: 199 Issue: 6 Pages: 893-906 Published: DEC 10 2012
- 2012, Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling By: Xu, Jianing; McEachern, Michael J. PLOS GENETICS Volume: 8 Issue: 11 Article Number: e1003017 Published: NOV 2012
- 2012, Maintenance of Very Long Telomeres by Recombination in the Kluyveromyces lactis stn1-M1 Mutant Involves Extreme Telomeric Turnover, Telomeric Circles, and Concerted Telomeric Amplification By: Xu, Jianing; McEachern, Michael J. MOLECULAR AND CELLULAR BIOLOGY Volume: 32 Issue: 15 Pages: 2992-3008 Published: AUG 2012
- 2012, Telomeres and telomerase in Candida albicans By: Yu, Eun Young MYCOSES Volume: 55 Issue: 3 Pages: e48-e59 Published: MAY 2012
- 2012, The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity By: Sarikaya, Buket Bozkurt; Zencir, Sevil; Somer, Nehir Unver; et al. RECORDS OF NATURAL PRODUCTS Volume: 6 Issue: 4 Pages: 381-385 Published: 2012
- 2012, New benzimidazole derivatives with potential cytotoxic activity - study of their stability by RP-HPLC By: Blaszczak-Swiatkiewicz, Katarzyna; Mirowski, Marek; Kaplinska, Katarzyna; et al. ACTA BIOCHIMICA POLONICA Volume: 59 Issue: 2 Pages: 279-288 Published: 2012
- 2012, Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents By: Zhan, Peng; Li, Dongyue; Li, Junyi; et al. MINI-REVIEWS IN ORGANIC CHEMISTRY Volume: 9 Issue: 4 Pages: 397-410 Published: NOV 2012
- 2012, Identification of Therapeutic and Diagnostic Targets Through Yeast Two Hybrid System: Molecular Biology in Medicine By: Freitas, Maria Joao; Korrodi-Gregorio, Luis; Esteves, Sara; et al. ACTA MEDICA PORTUGUESA Volume: 25 Issue: 6 Pages: 427-432 Published: NOV-DEC 2012
- 2012, The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity By: Sarikaya, Buket Bozkurt; Zencir, Sevil; Somer, Nehir Unver; et al. RECORDS OF NATURAL PRODUCTS Volume: 6 Issue: 4 Pages: 381-385 Published: 2012
- 2012, Interstitial Lung Damage Due to Cocaine Abuse: Pathogenesis, Pharmacogenomics and Therapy By: Drent, M.; Wijnen, P.; Bast, A. CURRENT MEDICINAL CHEMISTRY Volume: 19 Issue: 33 Pages: 5607-5611 Published: NOV 2012
- 2012, Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene By: Stolic, Ivana; Avdicevic, Monika; Bregovic, Nikola; et al. CROATICA CHEMICA ACTA Volume: 85 Issue: 4 Special Issue: SI Pages: 457-467 Published: DEC 2012
- 2012, Synthetic Routes to Symmetric Bisbenzimidazoles: A Review By: Khanna, Leena; Panda, Siva S.; Khanna, Pankaj MINI-REVIEWS IN ORGANIC CHEMISTRY Volume: 9 Issue: 4 Pages: 381-396 Published: NOV 2012
- 2012, Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy By: Wang, Xiu-Jun; Chu, Na-Ying; Wang, Qin-He; et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 22 Issue: 19 Pages: 6297-6300 Published: OCT 1 2012
- 2012, A new approach to the synthesis of 2-aryl-substituted benzimidazoles, quinazolines, and other related compounds and their antibacterial activity By: Los, Renata; Wesolowska-Trojanowska, Marta; Malm, Anna; et al. HETEROATOM CHEMISTRY Volume: 23 Issue: 3 Pages: 265-275 Published: 2012
- 2012, The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity By: Sarikaya, Buket Bozkurt; Zencir, Sevil; Somer, Nehir Unver; et al. RECORDS OF NATURAL PRODUCTS Volume: 6 Issue: 4 Pages: 381-385 Published: 2012
- 2012, Maintenance of Very Long Telomeres by Recombination in the Kluyveromyces lactis stn1-M1 Mutant Involves Extreme Telomeric Turnover, Telomeric Circles, and Concerted Telomeric Amplification By: Xu, Jianing; McEachern, Michael J. MOLECULAR AND CELLULAR BIOLOGY Volume: 32 Issue: 15 Pages: 2992-3008 Published: AUG 2012
- 2012, Expression of TIP-1 Confers Radioresistance of Malignant Glioma Cells By: Han, Miaojun; Wang, Hailun; Zhang, Hua-Tang; et al. PLOS ONE Volume: 7 Issue: 9 Article Number: e45402 Published: SEP 17 2012
- 2012, Specificity and Promiscuity in Human Glutaminase Interacting Protein Recognition: Insight from the Binding of the Internal and C-Terminal Motif By: Banerjee, Monimoy; Zoetewey, David L.; Ovee, Mohiuddin; et al. BIOCHEMISTRY Volume: 51 Issue: 35 Pages: 6950-6960 Published: SEP 4 2012
- 2012, SPPS: A Sequence-Based Method for Predicting Probability of Protein-Protein Interaction Partners By: Liu, Xinyi; Liu, Bin; Huang, Zhimin; et al. PLOS ONE Volume: 7 Issue: 1 Article Number: e30938 Published: JAN 26 2012
- 2012, Can cytogenetics explain the possible association between exposure to extreme low-frequency magnetic fields and Alzheimer's disease? By: Maes, Annemarie; Verschaeve, Luc JOURNAL OF APPLIED TOXICOLOGY Volume: 32 Issue: 2 Pages: 81-87 Published: FEB 2012
- 2012, The role of zinc supplementation in the inhibition of tissue damage caused by exposure to electromagnetic field in rat lung and liver tissues By: Baltaci, A. K.; Mogulkoc, R.; Salbacak, A.; et al. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY Volume: 113 Issue: 7 Pages: 400-403 Published: 2012
- 2012, Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines By: Kulkarni, Hemant; Goering, Harald H. H.; Diego, Vincent; et al. BMC MEDICAL GENOMICS Volume: 5 Article Number: 37 Published: AUG 23 2012
- 2012, Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy By: Bailly, Christian CHEMICAL REVIEWS Volume: 112 Issue: 7 Pages: 3611-3640 Published: JUL 2012
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells By: Staedler, Davide; Idrizi, Elita; Kenzaoui, Blanka Halamoda; et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY Volume: 68 Issue: 5 Pages: 1161-1172 Published: NOV 2011
- 2011, Evaluation of the mutagenic/clastogenic potential of 3,6-di-substituted acridines targeted for anticancer chemotherapy By: Di Giorgio, Carole; Benchabane, Yohann; Boyer, Gerard; et al. FOOD AND CHEMICAL TOXICOLOGY Volume: 49 Issue: 11 Pages: 2773-2779 Published: NOV 2011
- 2011, Synthesis, Cytotoxicity and Topoisomerase II Inhibitory Activity of Benzonaphthofurandiones By: Rhee, Hee-Kyung; Kwon, Youngjoo; Chung, Hwa-Jin; et al. BULLETIN OF THE KOREAN CHEMICAL SOCIETY Volume: 32 Issue: 7 Pages: 2391-2396 Published: JUL 20 2011
- 2011, Sleeping Sickness Pathogen (Trypanosoma brucei) and Natural Products: Therapeutic Targets and Screening Systems By: Hannaert, Veronique PLANTA MEDICA Volume: 77 Issue: 6 Pages: 586-597 Published: APR 2011
- 2011, Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety By: Jeong, Byeong-Seon; Choi, Hoyoung; Thapa, Pritam; et al. BULLETIN OF THE KOREAN CHEMICAL SOCIETY Volume: 32 Issue: 1 Pages: 303-306 Published: JAN 20 2011
- 2011, Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex By: Kranzusch, Philip J.; Whelan, Sean P. J. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 108 Issue: 49 Pages: 19743-19748 Published: DEC 6 2011
- 2011, Molecular Determinants of Arenavirus Z Protein Homo-Oligomerization and L Polymerase Binding By: Eugenia Loureiro, Maria; Wilda, Maximiliano; Levingston Macleod, Jesica M.; et al. JOURNAL OF VIROLOGY Volume: 85 Issue: 23 Pages: 12304-12314 Published: DEC 2011
- 2011, Homeoprotein Hex is expressed in mouse developing chondrocytes By: Morimoto, Riyo; Yamamoto, Akitsugu; Akimoto, Yoshihiro; et al. JOURNAL OF BIOCHEMISTRY Volume: 150 Issue: 1 Pages: 61-71 Published: JUL 2011
- 2011, CYP26B1 is a novel candidate gene for betel quid-related oral squamous cell carcinoma By: Chen, Ping-Ho; Lee, Ka-Wo; Chen, Chung-Ho; et al. ORAL ONCOLOGY Volume: 47 Issue: 7 Pages: 594-600 Published: JUL 2011
- 2011, Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver By: Tatematsu, Kenjiro; Koide, Akihiro; Hirose, Masao; et al. MUTAGENESIS Volume: 26 Issue: 2 Pages: 323-330 Published: MAR 2011
- 2011, Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity By: Basenko, Evelina; Topcu, Zeki; McEachern, Michael J. EUKARYOTIC CELL Volume: 10 Issue: 8 Pages: 1131-1142 Published: AUG 2011
- 2011, Recombination Can Cause Telomere Elongations as Well as Truncations Deep within Telomeres in Wild-Type Kluyveromyces lactis Cells By: Bechard, Laura H.; Jamieson, Nathan; McEachern, Michael J. EUKARYOTIC CELL Volume: 10 Issue: 2 Pages: 226-236 Published: FEB 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Secalonic acid D as a novel DNA topoisomerase I inhibitor from marine lichen-derived fungus Gliocladium sp T31 By: Hong, Ren PHARMACEUTICAL BIOLOGY Volume: 49 Issue: 8 Pages: 796-799 Published: AUG 2011
- 2011, Survey of Arabidopsis- and Human-type Telomere Repeats in Plants Using Fluorescence in situ Hybridisation By: Shibata, Fukashi; Hizume, Masahiro CYTOLOGIA Volume: 76 Issue: 3 Pages: 353-360 Published: SEP 2011
- 2011, Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity By: Basenko, Evelina; Topcu, Zeki; McEachern, Michael J. EUKARYOTIC CELL Volume: 10 Issue: 8 Pages: 1131-1142 Published: AUG 2011
- 2011, Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty By: Ozsarlak-Sozer, Gonen; Kerry, Zeliha; Gokce, Goksel; et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY Volume: 67 Issue: 1 Pages: 35-42 Published: MAR 2011
- 2011, Recombination Can Cause Telomere Elongations as Well as Truncations Deep within Telomeres in Wild-Type Kluyveromyces lactis Cells By: Bechard, Laura H.; Jamieson, Nathan; McEachern, Michael J. EUKARYOTIC CELL Volume: 10 Issue: 2 Pages: 226-236 Published: FEB 2011
- 2011, Telomeric recombination induced by dysfunctional telomeres By: Brault, Marie Eve; Autexier, Chantal MOLECULAR BIOLOGY OF THE CELL Volume: 22 Issue: 2 Pages: 179-188 Published: JAN 15 2011
- 2011, Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs By: Al-Tel, Taleb H.; Al-Qawasmeh, Raed A.; Zaarour, Rania EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 46 Issue: 5 Pages: 1874-1881 Published: MAY 2011
- 2011, Crystal Structure and Theoretical Calculation of 1,4-Bis(1-ferrocenesulfonyl-2-benzimidazolyl) Butane By: Yue Kefen; Zhuo Fei; Zhai Gaohong; et al. CHINESE JOURNAL OF CHEMISTRY Volume: 29 Issue: 2 Pages: 223-228 Published: FEB 2011
- 2011, Synthesis and antimicrobial activities of novel 8-(1-alkyl/alkylsulphonyl/alkoxycarbonyl-benzimidazol-2-ylmethoxy)-5-chloroquinolines By: Chaudhari, Raju B.; Rindhe, Sahebrao S. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY Volume: 76 Issue: 9 Pages: 1199-1206 Published: 2011
- 2011, Synthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives By: Kucukbay, Hasan; Yilmaz, Ulku; Sireci, Nihat; et al. TURKISH JOURNAL OF CHEMISTRY Volume: 35 Issue: 4 Pages: 561-571 Published: 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein By: Zencir, Sevil; Ovee, Mohiuddin; Dobson, Melanie J.; et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 411 Issue: 4 Pages: 792-797 Published: AUG 12 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty By: Ozsarlak-Sozer, Gonen; Kerry, Zeliha; Gokce, Goksel; et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY Volume: 67 Issue: 1 Pages: 35-42 Published: MAR 2011
- 2011, Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer By: Ruwali, Munindra; Singh, Madhu; Pant, Mohan C.; et al. XENOBIOTICA Volume: 41 Issue: 12 Pages: 1122-1130 Published: DEC 2011
- 2011, Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma By: Azarpira, Negar; Ashraf, Mohamad Javad; Khademi, Bigan; et al. MOLECULAR BIOLOGY REPORTS Volume: 38 Issue: 8 Pages: 5443-5448 Published: NOV 2011
- 2011, Development of Cocaine-Induced Interstitial Lung Damage in Two CYP2C and VKORC1 Variant Allele Carriers By: Wijnen, Petal A. H. M.; Bekers, Otto; Drent, Marjolein MOLECULAR DIAGNOSIS & THERAPY Volume: 15 Issue: 3 Pages: 177-180 Published: 2011
- 2011, Boric Acid-Catalyzed Direct Condensation of Carboxylic Acids with Benzene-1,2-diamine into Benzimidazoles By: Maras, Nenad; Kocevar, Marijan HELVETICA CHIMICA ACTA Volume: 94 Issue: 10 Pages: 1860-1874 Published: OCT 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, Oxidative Stress and Apoptosis in Relation to Exposure to Magnetic Field By: Emre, Mustafa; Cetiner, Salih; Zencir, Sevil; et al. CELL BIOCHEMISTRY AND BIOPHYSICS Volume: 59 Issue: 2 Pages: 71-77 Published: MAR 2011
- 2011, Effect of Ocimum basilicum on apoptosis in testis of rats after exposure to electromagnetic field By: Khaki, Arash; Fathiazad, Fatemeh; Nouri, Mohammad; et al. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY Volume: 5 Issue: 12 Pages: 1534-1537 Published: SEP 2011
- 2011, Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition By: Baran, Y.; Zencir, S.; Cakir, Z.; et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 36 Issue: 6 Pages: 673-679 Published: DEC 2011
- 2011, 3-(4-Chlorobenzoyl)-4-(4-chlorophenyl)-1-phenethylpiperidin-4-ol By: Aydin, Abdullah; Akkurt, Mehmet; Mete, Ebru; et al. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE Volume: 67 Pages: O1447-U982 Part: 6 Published: JUN 2011
- 2011, Synthesis and Antifungal Evaluation of 1-Aryl-2-dimethylaminomethyl-2-propen-1-one Hydrochlorides By: Mete, Ebru; Gul, Halise Inci; Bilginer, Sinan; et al. MOLECULES Volume: 16 Issue: 6 Pages: 4660-4671 Published: JUN 2011
- 2011, Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility By: Luo, Ya-ping; Chen, Han-chun; Khan, Md Asaduzzaman; et al. TUMOR BIOLOGY Volume: 32 Issue: 1 Pages: 215-222 Published: FEB 2011
- 2011, Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty By: Ozsarlak-Sozer, Gonen; Kerry, Zeliha; Gokce, Goksel; et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY Volume: 67 Issue: 1 Pages: 35-42 Published: MAR 2011
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- 2010, Concise route to the key intermediate for divergent synthesis of C7-substituted fluoroquinolone derivatives Author(s): Zhang X, Mu F, Robinson B, et al. Source: TETRAHEDRON LETTERS Volume: 51 Issue: 4 Pages: 600-601 Published: JAN 27 2010
- 2010, Study of the Prediction System for Clinical Response to M-VAC Neoadjuvant Chemotherapy for Bladder Cancer Author(s): Takata R, Obara W, Fujioka T Source: AKTUELLE UROLOGIE Volume: 41 Pages: S41-S45 Supplement: Suppl. 1 Published: JAN 2010
- 2010, 2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study Author(s): Thapa P, Karki R, Thapa U, et al. Source: BIOORGANIC & MEDICINAL CHEMISTRY Volume: 18 Issue: 1 Pages: 377-386 Published: JAN 1 2010
- 2010, The flexible C-terminal arm of the Lassa arenavirus Z-protein mediates interactions with multiple binding partners Author(s): May ER, Armen RS, Mannan AM, et al. Source: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS Volume: 78 Issue: 10 Pages: 2251-2264 Published: AUG 1 2010
- 2010, PRH/Hhex Controls Cell Survival through Coordinate Transcriptional Regulation of Vascular Endothelial Growth Factor Signaling Author(s): Noy P, Williams H, Sawasdichai A, et al.Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 30 Issue: 9 Pages: 2120-2134 Published: MAY 1 2010
- 2010, Interaction between Hhex and SOX13 Modulates Wnt/TCF Activity Author(s): Marfil V, Moya M, Pierreux CE, et al. Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 285 Issue: 8 Pages: 5726-5737 Published: FEB 19 2010
- 2010, Association of functionally important polymorphisms in cytochrome P450s with squamous cell carcinoma of head and neck Author(s): Ruwali M, Parmar D Source: INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY Volume: 48 Issue: 7 Special Issue: Sp. Iss. SI Pages: 651-665 Published: JUL 2010
- 2010, Metabolic Activation of Heterocyclic Amines and Expression of CYP1A1 in the Tongue Author(s): Takiguchi M, Darwish WS, Ikenaka Y, et al.Source: TOXICOLOGICAL SCIENCES Volume: 116 Issue: 1 Pages: 79-91 Published: JUL 2010
- 2010, Cancer Epidemiology in South Asia - Past, Present and Future Author(s): Moore MA, Ariyaratne Y, Badar F, et al. Source: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION Volume: 11 Pages: 49-66 Supplement: Suppl. 2 Published: APR 2010
- 2010, cular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment Author(s): Rodriguez-Antona C, Gomez A, Karlgren M, et al. Source: HUMAN GENETICS Volume: 127 Issue: 1 Pages: 1-17 Published: JAN 2010
- 2010, cular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment Author(s): Rodriguez-Antona C, Gomez A, Karlgren M, et al. Source: HUMAN GENETICS Volume: 127 Issue: 1 Pages: 1-17 Published: JAN 2010
- 2010, Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination Author(s): Basenko EY, Cesare AJ, Iyer S, et al. Source: NUCLEIC ACIDS RESEARCH Volume: 38 Issue: 1 Pages: 182-189 Published: JAN 2010
- 2010, Gel mobilities of linking-number topoisomers and their dependence on DNA helical repeat and elasticity Author(s): Vetcher AA, McEwen AE, Abujarour R, et al. Source: BIOPHYSICAL CHEMISTRY Volume: 148 Issue: 1-3 Pages: 104-111 Published: MAY 2010
- 2010, Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid Author(s): Santos RC, Salvador JAR, Marin S, et al. Source: BIOORGANIC & MEDICINAL CHEMISTRY Volume: 18 Issue: 12 Pages: 4385-4396 Published: JUN 15 2010
- 2010, Rap1 in Candida albicans: an Unusual Structural Organization and a Critical Function in Suppressing Telomere Recombination Author(s): Yu EY, Yen WF, Steinberg-Neifach O, et al.Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 30 Issue: 5 Pages: 1254-1268 Published: MAR 2010
- 2010, Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination Author(s): Basenko EY, Cesare AJ, Iyer S, et al. Source: NUCLEIC ACIDS RESEARCH Volume: 38 Issue: 1 Pages: 182-189 Published: JAN 2010
- 2010, The mRNA Expression of Cytochrome P450 Isoforms in Human Gastric Tissue Author(s): Canturk P, Caner V, Oruc N, et al. Source: HEPATO-GASTROENTEROLOGY Volume: 57 Issue: 98 Pages: 372-376 Published: MAR-APR 2010
- 2010, A PCR-after-ligation method for cloning of multiple DNA inserts Author(s): An YF, Wu WF, Lv AG Source: ANALYTICAL BIOCHEMISTRY Volume: 402 Issue: 2 Pages: 203-205 Published: JUL 15 2010
- 2010, A PCR-after-ligation method for cloning of multiple DNA inserts Author(s): An YF, Wu WF, Lv AG Source: ANALYTICAL BIOCHEMISTRY Volume: 402 Issue: 2 Pages: 203-205 Published: JUL 15 2010
- 2010, The mRNA Expression of Cytochrome P450 Isoforms in Human Gastric Tissue Author(s): Canturk P, Caner V, Oruc N, et al. Source: HEPATO-GASTROENTEROLOGY Volume: 57 Issue: 98 Pages: 372-376 Published: MAR-APR 2010
- 2010, Update Information on Drug Metabolism Systems-2009, Part II. Summary of Information on the Effects of Diseases and Environmental Factors on Human Cytochrome P450 (CYP) Enzymes and Transporters Author(s): Rendic S, Guengerich FP Source: CURRENT DRUG METABOLISM Volume: 11 Issue: 1 Pages: 4-84 Published: JAN 2010
- 2010, 1,5-Bis (2-Hydroxyphenyl)Pent-1,4-Diene-3-One: A Lead Compound for the Development of Broad-spectrum Antibacterial Agents Author(s): Rani A, Jain S, Kumar R, et al. Source: SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE Volume: 63 Pages: 31-35 Published: 2010
- 2010, Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives Author(s): Refaat HM Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 45 Issue: 7 Pages: 2949-2956 Published: JUL 2010
- 2010, Rap1 in Candida albicans: an Unusual Structural Organization and a Critical Function in Suppressing Telomere Recombination Author(s): Yu EY, Yen WF, Steinberg-Neifach O, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 30 Issue: 5 Pages: 1254-1268 Published: MAR 2010
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- 2009, Mutant Telomeric Repeats in Yeast Can Disrupt the Negative Regulation of Recombination-Mediated Telomere Maintenance and Create an Alternative Lengthening of Telomeres-Like Phenotype Author(s): Bechard LH, Butuner BD, Peterson GJ, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 29 Issue: 3 Pages: 626-639 Published: FEB 1 2009
- 2009, Sun J, Yu EY, Yang YT, et al. Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres GENES & DEVELOPMENT 23 24 2900-2914 DEC 15 2009
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- 2009, Lopez-Lazaro M Distribution and Biological Activities of the Flavonoid Luteolin MINI-REVIEWS IN MEDICINAL CHEMISTRY 9 1 31-59 JAN 2009
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- 2009, Alpan AS, Zencir S, Zupko I, et al. Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 24 3 844-849 2009
- 2009, Coban G, Zencir S, Zupko I, et al. Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44 5 2280-2285 MAY 2009
- 2009, Comparative evaluation of polymeric and amphiphilic cyclodextrin nanoparticles for effective camptothecin delivery Author(s): Cirpanli Y, Bilensoy E, Dogan AL, et al.Source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS Volume: 73 Issue: 1 Pages: 82-89 Published: SEP 2009
- 2009, Protection of mouse bone marrow from etoposide-induced genomic damage by dexrazoxane Author(s): Attia SM, Al-Anteet AA, Al-Rasheed NM, et al.Source: CANCER CHEMOTHERAPY AND PHARMACOLOGY Volume: 64 Issue: 4 Pages: 837-845 Published: SEP 2009
- 2009, Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells Author(s): Youns M, Efferth T, Reichling J, et al. Source: BIOCHEMICAL PHARMACOLOGY Volume: 78 Issue: 3 Pages: 273-283 Published: AUG 1 2009
- 2009, Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei Author(s): Steverding D, Wang X Source: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Volume: 63 Issue: 6 Pages: 1293-1295 Published: JUN 2009
- 2009, A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH Author(s): Ploski JE, Topisirovic I, Park KW, et al.Source: MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 332 Issue: 1-2 Pages: 173-181 Published: DEC 2009
- 2009, CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding Author(s): Soufi A, Noy P, Buckle M, et al. Source: NUCLEIC ACIDS RESEARCH Volume: 37 Issue: 10 Pages: 3288-3300 Published: JUN 2009
- 2009, The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors Author(s): Desjobert C, Noy P, Swingler T, et al. Source: BIOCHEMICAL JOURNAL Volume: 417 Pages: 121-132 Part: Part 1 Published: JAN 1 2009
- 2009, Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome Author(s): Ruwali M, Pant MC, Shah PP, et al. Source: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS Volume: 669 Issue: 1-2 Pages: 36-41 Published: OCT 2 2009
- 2009, Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits Author(s): Ozsarlak-Sozer G, Kerry Z, Oran I, et al.Source: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY Volume: 65 Issue: 3 Pages: 243-249 Published: SEP 2009
- 2009, Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata Author(s): Kachouri-Lafond R, Dujon B, Gilson E, et al.Source: FEBS LETTERS Volume: 583 Issue: 22 Pages: 3605-3610 Published: NOV 19 2009
- 2009, Telomeric circles: universal players in telomere maintenance? Author(s): Tomaska L, Nosek J, Kramara J, et al. Source: NATURE STRUCTURAL & MOLECULAR BIOLOGY Volume: 16 Issue: 10 Pages: 1010-1015 Published: OCT 2009
- 2009, Extrachromosomal Circular DNA in Eukaryotes: Possible Involvement in the Plasticity of Tandem Repeats Author(s): Cohen S, Segal D Source: CYTOGENETIC AND GENOME RESEARCH Volume: 124 Issue: 3-4 Pages: 327-338 Published: 2009
- 2009, Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres Author(s): Muntoni A, Neumann AA, Hills M, et al. Source: HUMAN MOLECULAR GENETICS Volume: 18 Issue: 6 Pages: 1017-1027 Published: MAR 15 2009
- 2009, Discovery of a Novel Series of Quinolone and Naphthyridine Derivatives as Potential Topoisomerase I Inhibitors by Scaffold Modification Author(s): You QD, Li ZY, Huang CH, et al.Source: JOURNAL OF MEDICINAL CHEMISTRY Volume: 52 Issue: 18 Pages: 5649-5661 Published: SEP 24 2009
- 2009, Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres Author(s): Sun J, Yu EY, Yang YT, et al. Source: GENES & DEVELOPMENT Volume: 23 Issue: 24 Pages: 2900-2914 Published: DEC 15 2009
- 2009, Evidence for an Additional Base-Pairing Element between the Telomeric Repeat and the Telomerase RNA Template in Kluyveromyces lactis and Other Yeasts Author(s): Wang ZR, Guo LL, Chen LZ, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 29 Issue: 20 Pages: 5389-5398 Published: OCT 15 2009
- 2008, Lokaj J, Kettmann V, Solcan T, et al. 1-Methyl-6-nitro-1H-benzimidazole ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE 64 O671-U972 Part 4 APR 2008
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- 2008, Pavek P, Dvorak Z Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues CURRENT DRUG METABOLISM 9 2 129-143 FEB 2008
- 2008, Cesare AJ, Reddel RR Telomere uncapping and alternative lengthening of telomeres MECHANISMS OF AGEING AND DEVELOPMENT 129 1-2 99-108 JAN-FEB 2008
- 2008, Makovets S, Williams TL, Blackburn EH The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-mendelian characteristic in cells lacking telomerase GENETICS 178 1 245-257 JAN 2008
- 2008, Cesare AJ, Groff-Vindman C, Compton SA, et al. Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain MOLECULAR AND CELLULAR BIOLOGY 28 1 20-29 JAN 2008
- 2008, Capul AA, de la Torre JC A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding VIROLOGY 382 1 107-114 DEC 5 2008
- 2008, Borden KLB Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: Can we fit the pieces together using an RNA regulon? BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1783 11 Sp. Iss. SI 2145-2154 NOV 2008
- 2008, PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate Author(s): Soufi A, Jayaraman PS Source: BIOCHEMICAL JOURNAL Volume: 412 Pages: 399-413 Part: Part 3 Published: JUN 15 2008
- 2008, Abbaszadegan MR, Jafarzadeh N, Sankian M, et al. Truncated MTA-1: A pitfall in ELISA-based immunoassay of HTLV-1 infection JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 2008
- 2008, Han HJ, Tan NH, Zeng GZ, et al. Natural inhibitors of DNA topoisomerase I with cytotoxicities CHEMISTRY & BIODIVERSITY 5 7 1364-1368 2008
- 2008, Reymann S, Borlak J Topoisomerase II inhibition involves characteristic chromosomal expression patterns BMC GENOMICS 9 JUL 8 2008
- 2008, Marverti G, Cusumano M, Ligabue A, et al. Studies on the anti-proliferative effects of novel DNA-intercalating bipyridyl-thiourea-Pt(II) complexes against cisplatin-sensitive and -resistant human ovarian cancer cells JOURNAL OF INORGANIC BIOCHEMISTRY 102 4 699-712 APR 2008
- 2008, DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicity Author(s): Di Giorgio C, Nikoyan A, Decorne L, et al. Source: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS Volume: 650 Issue: 2 Pages: 104-114 Published: FEB 29 2008
- 2008, Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase Author(s): Topcu Z, Ozturk B, Kucukoglu O, et al. Source: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES Volume: 63 Issue: 1-2 Pages: 69-74 Published: JAN-FEB 2008
- 2008, Title: CYP2A6 polymorphisms and risk for tobacco-related cancers Author(s): Rossini A, Simao TD, Albano RM, et al. Source: PHARMACOGENOMICS Volume: 9 Issue: 11 Pages: 1737-1752 Published: NOV 2008
- 2008, Genetic polymorphisms and head and neck cancer risk (Review) Author(s): Hiyama T, Yoshihara M, Tanaka S, et al. Source: INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 32 Issue: 5 Pages: 945-973 Published: MAY 2008
- 2008, Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues Author(s): Pavek P, Dvorak Z Source: CURRENT DRUG METABOLISM Volume: 9 Issue: 2 Pages: 129-143 Published: FEB 2008
- 2008, CYP2A6 polymorphisms and risk for tobacco-related cancers Author(s): Rossini A, Simao TD, Albano RM, et al. Source: PHARMACOGENOMICS Volume: 9 Issue: 11 Pages: 1737-1752 Published: NOV 2008
- 2008, Detection of Cytochrome P450-2A6,-3A5 and 4B1 with Real-Time Polymerase Chain Reaction in Prostate Tissue Author(s): Zencir S, Alptekin D, Celiktas M, et al. Source: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES Volume: 63 Issue: 9-10 Pages: 780-784 Published: SEP-OCT 2008
- 2008, CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives Author(s): Sinues B, Fanlo A, Mayayo E, et al. Source: HUMAN & EXPERIMENTAL TOXICOLOGY Volume: 27 Issue: 5 Pages: 367-372 Published: MAY 2008
- 2008, Genetic polymorphisms and head and neck cancer risk (Review) Author(s): Hiyama T, Yoshihara M, Tanaka S, et al. Source: INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 32 Issue: 5 Pages: 945-973 Published: MAY 2008
- 2008, Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues Author(s): Pavek P, Dvorak Z Source: CURRENT DRUG METABOLISM Volume: 9 Issue: 2 Pages: 129-143 Published: FEB 2008
- 2008, Telomere uncapping and alternative lengthening of telomeres Author(s): Cesare AJ, Reddel RR Source: MECHANISMS OF AGEING AND DEVELOPMENT Volume: 129 Issue: 1-2 Pages: 99-108 Published: JAN-FEB 2008
- 2008, The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-mendelian characteristic in cells lacking telomerase Author(s): Makovets S, Williams TL, Blackburn EH Source: GENETICS Volume: 178 Issue: 1 Pages: 245-257 Published: JAN 2008
- 2008, Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain Author(s): Cesare AJ, Groff-Vindman C, Compton SA, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 28 Issue: 1 Pages: 20-29 Published: JAN 2008
- 2008, Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase Author(s): Topcu Z, Ozturk B, Kucukoglu O, et al. Source: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES Volume: 63 Issue: 1-2 Pages: 69-74 Published: JAN-FEB 2008
- 2007, PKC eta expression contributes to the resistance of Hodgkin's lymphoma cell lines to apoptosis Author(s): Abu-Ghanem S, Oberkovitz G, Benharroch D, et al. Source: CANCER BIOLOGY & THERAPY Volume: 6 Issue: 9 Pages: 1375-1380 Published: SEP 2007
- 2007, Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I Author(s): Li XM, Ng MTT, Wang YF, et al. Source: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 17 Issue: 17 Pages: 4967-4971 Published: SEP 1 2007
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- 2007, Down-regulation of human topoisomerase II alpha expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions Author(s): Williams AO, Isaacs RJ, Stowell KM Source: BMC MOLECULAR BIOLOGY Volume: 8 Article Number: 36 Published: MAY 20 2007
- 2007, The broken genome: Genetic and pharmacologic approaches to breaking DNA Author(s): Woo L, Onel K, Ellis NA Source: ANNALS OF MEDICINE Volume: 39 Issue: 3 Pages: 208-218 Published: 2007
- 2007, Wang L, Roy SK, Eastmond DA Source: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS Volume: 616 Issue: 1-2 Pages: 70-82 Published: MAR 1 2007
- 2007, RT-PCR-based cytochrome P450 expression profile of oral tissue samples Author(s): Sarikaya D, Chiba I, Bilgen C, et al. Source: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 32 Issue: 5 Pages: 445-448 Published: OCT 2007
- 2007, CYP2A6 overexpression in human lung cancers correlates with a high malignant status Author(s): Matsuda Y, Yamakawa K, Saoo K, et al. Source: ONCOLOGY REPORTS Volume: 18 Issue: 1 Pages: 53-57 Published: JUL 2007
- 2007, RT-PCR-based cytochrome P450 expression profile of oral tissue samples Author(s): Sarikaya D, Chiba I, Bilgen C, et al. Source: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Volume: 32 Issue: 5 Pages: 445-448 Published: OCT 2007
- 2007, CYP2A6 overexpression in human lung cancers correlates with a high malignant status Author(s): Matsuda Y, Yamakawa K, Saoo K, et al. Source: ONCOLOGY REPORTS Volume: 18 Issue: 1 Pages: 53-57 Published: JUL 2007
- 2007, Evidence that a RecQ helicase slows senescence by resolving recombining telomeres Author(s): Lee JY, Kozak M, Martin JD, et al. Source: PLOS BIOLOGY Volume: 5 Issue: 6 Pages: 1334-1344 Published: JUN 2007
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- 2006, Title: Lassa virus genome Author(s): Lukashevich IS, Salvato MS Source: CURRENT GENOMICS Volume: 7 Issue: 6 Pages: 351-379 Published: SEP 2006
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- 2006, Purification and characterisation of the PRH homeodomain: Removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction Author(s): Soufi A, Gaston K, Jayaraman PS Source: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Volume: 39 Issue: 1-3 Special Issue: Sp. Iss. SI Pages: 45-50 Published: AUG 15 2006
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- 2006, Mitoxantrone-associated acute myelogenous leukemia in a patient with high-risk adenocarcinoma of the prostate: A case report and brief review Author(s): Bowles DW, Flaig TW Source: CANCER INVESTIGATION Volume: 24 Issue: 5 Pages: 517-520 Published: AUG 2006
- 2006, Identification and classification of differentially expressed genes in non-small cell lung cancer by expression profiling on a global human 59.620-element oligonucleotide array Author(s): Hofmann HS, Bartling B, Simm A, et al. Source: ONCOLOGY REPORTS Volume: 16 Issue: 3 Pages: 587-595 Published: SEP 2006
- 2006, Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity Author(s): Goodell JR, Madhok AA, Hiasa H, et al. Source: BIOORGANIC & MEDICINAL CHEMISTRY Volume: 14 Issue: 16 Pages: 5467-5480 Published: AUG 15 2006
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- 2006, 3,3 '-Diindolylmethane is a novel topoisomerase II alpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells Author(s): Gong YX, Firestone GL, Bjeldanes LF Source: MOLECULAR PHARMACOLOGY Volume: 69 Issue: 4 Pages: 1320-1327 Published: APR 2006
- 2006, Enticed into molecular toxicology Author(s): Kamataki T Source: YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Volume: 126 Issue: 12 Pages: 1309-1318 Published: 2006
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- 2006, Comparative Cytochrome P450-1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level Author(s): Sarikaya D, Bilgen C, Kamataki T, et al. Source: BIOPHARMACEUTICS & DRUG DISPOSITION Volume: 27 Issue: 8 Pages: 353-359 Published: NOV 2006
- 2006, Break-induced replication and recombinational telomere elongation in yeast Author(s): McEachern MJ, Haber JE Source: ANNUAL REVIEW OF BIOCHEMISTRY Volume: 75 Pages: 111-135 Published: 2006
- 2006, Modulation of telomere terminal structure by telomerase components in Candida albicans Author(s): Steinberg-Neifach O, Lue NF Source: NUCLEIC ACIDS RESEARCH Volume: 34 Issue: 9 Pages: 2710-2722 Published: 2006
- 2006, Screening for telomeric recombination in wild-type Kluyveromyces lactis Author(s): Natarajan S, Nickles K, McEachern MJ Source: FEMS YEAST RESEARCH Volume: 6 Issue: 3 Pages: 442-448 Published: MAY 2006
- 2006, Telomere dynamics in genome stability Author(s): Bhattacharyya MK, Lustig AJ Source: TRENDS IN BIOCHEMICAL SCIENCES Volume: 31 Issue: 2 Pages: 114-122 Published: FEB 2006
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- 2005, The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus Author(s): Djavani M, Topisirovic I, Zapata JC, et al. Source: JOURNAL OF VIROLOGY Volume: 79 Issue: 4 Pages: 2461-2473 Published: FEB 2005
- 2005, Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels Author(s): Topisirovic I, Kentsis A, Perez JM, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 25 Issue: 3 Pages: 1100-1112 Published: FEB 2005
- 2005, Hibbert EG, Baganz F, Hailes HC, et al. Directed evolution of biocatalytic processes BIOMOLECULAR ENGINEERING 22 1-3 11-19 JUN 2005
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- 2005, Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase Author(s): Wei H, Ruthenburg AJ, Bechis SK, et al. Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 280 Issue: 44 Pages: 37041-37047 Published: NOV 4 2005
- 2005, Novel antitrypanosomal agents Author(s): Steverding D, Tyler KM Source: EXPERT OPINION ON INVESTIGATIONAL DRUGS Volume: 14 Issue: 8 Pages: 939-955 Published: AUG 2005
- 2005, Relationship between topoisomerase II-DNA cleavable complexes, apoptosis and cytotoxic activity of anthracyclines in human cervix carcinoma cells Author(s): Gruber BM, Anuszewska EL, Bubko I, et al. Source: ANTICANCER RESEARCH Volume: 25 Issue: 3B Pages: 2193-2198 Published: MAY-JUN 2005
- 2005, Medicinal mushroom modulators of molecular targets as cancer therapeutics Author(s): Zaidman BZ, Yassin M, Mahajna J, et al. Source: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY Volume: 67 Issue: 4 Pages: 453-468 Published: JUN 2005
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- 2005, Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling Author(s): Takata R, Katagiri T, Kanehira M, et al. Source: CLINICAL CANCER RESEARCH Volume: 11 Issue: 7 Pages: 2625-2636 Published: APR 1 2005
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- 2005, Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas Author(s): Miyazaki M, Yamazaki H, Takeuchi H, et al. Source: CARCINOGENESIS Volume: 26 Issue: 11 Pages: 1947-1955 Published: NOV 2005
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- 2005, Angiotensin-converting enzyme gene insertion/deletion polymorphism is associated with risk of oral precancerous lesion in betel quid chewers Author(s): Chung FM, Yang YH, Chen CH, et al. Source: BRITISH JOURNAL OF CANCER Volume: 93 Issue: 5 Pages: 602-606 Published: SEP 5 2005
- 2005, Three haplotypes associated with CYP2A6 phenotypes in Caucasians Author(s): Haberl M, Anwald B, Klein K, et al. Source: PHARMACOGENETICS AND GENOMICS Volume: 15 Issue: 9 Pages: 609-624 Published: SEP 2005
- 2005, Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108 Author(s): Miyazaki M, Sugawara E, Yoshimura T, et al. Source: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS Volume: 581 Issue: 1-2 Pages: 165-171 Published: MAR 7 2005
- 2005, CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians Author(s): Vasconcelos GM, Struchiner CJ, Suarez-Kurtz G Source: PHARMACOGENOMICS JOURNAL Volume: 5 Issue: 1 Pages: 42-48 Published: 2005
- 2005, 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6 Author(s): Denton TT, Zhang XD, Cashman JR Source: JOURNAL OF MEDICINAL CHEMISTRY Volume: 48 Issue: 1 Pages: 224-239 Published: JAN 13 2005
- 2005, Integrative epidemiology: From risk assessment to outcome prediction Author(s): Spitz MR, Wu XF, Mills G Source: JOURNAL OF CLINICAL ONCOLOGY Volume: 23 Issue: 2 Pages: 267-275 Published: JAN 10 2005
- 2005, A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT Author(s): Cerone MA, Autexier C, Londono-Vallejo JA, et al. Source: ONCOGENE Volume: 24 Issue: 53 Pages: 7893-7901 Published: NOV 24 2005
- 2005, A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast Author(s): Iyer S, Chadha AD, McEachern MJ Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 25 Issue: 18 Pages: 8064-8073 Published: SEP 2005
- 2005, Evidence for rolling circle replication of tandem genes in Drosophila Author(s): Cohen S, Agmon N, Yacobi K, et al. Source: NUCLEIC ACIDS RESEARCH Volume: 33 Issue: 14 Pages: 4519-4526 Published: 2005
- 2005, Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles Author(s): Groff-Vindman C, Cesare AJ, Natarajan S, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 25 Issue: 11 Pages: 4406-4412 Published: JUN 2005
- 2004, The proline-rich homeodomain protein recruits members of the Groucho/transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells Author(s): Swingler TE, Bess KL, Yao J, et al. Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Issue: 33 Pages: 34938-34947 Published: AUG 13 2004
- 2004, Title: Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein Author(s): Suico MA, Yoshida H, Seki Y, et al. Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 279 Issue: 18 Pages: 19091-19098 Published: APR 30 2004
- 2004, Effective and robust plasmid topology analysis and the subsequent characterization of the plasmid isoforms thereby observed Author(s): Molloy MJ, Hall VS, Bailey SI, et al. Source: NUCLEIC ACIDS RESEARCH Volume: 32 Issue: 16 Article Number: e129 Published: 2004
- 2004, Lee YS, Bergson P, He WS, et al. Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin CHEMISTRY & BIOLOGY 11 8 1139-1146 AUG 2004
- 2004, Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and-9 in HL-60 cells by a mechanism which does not involve Fas signaling Author(s): Perchellet EM, Wang Y, Weber RL, et al. Source: ANTI-CANCER DRUGS Volume: 15 Issue: 10 Pages: 929-946 Published: NOV 2004
- 2004, Mechanism targeted discovery of antitumor marine natural products Author(s): Nagle DG, Zhou YD, Mora FD, et al. Source: CURRENT MEDICINAL CHEMISTRY Volume: 11 Issue: 13 Pages: 1725-1756 Published: JUL 2004
- 2004, Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila Somatic Mutation and Recombination Test Author(s): Lehmann M, Vilar KD, Franco A, et al. Source: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS Volume: 43 Issue: 4 Pages: 250-257 Published: 2004
- 2004, Sphingolipid metabolism enzymes as targets for anticancer therapy Author(s): Kok JW, Sietsma H Source: CURRENT DRUG TARGETS Volume: 5 Issue: 4 Pages: 375-382 Published: MAY 2004
- 2004, Down-regulation of human topoisomerase II alpha correlates with altered expression of transcriptional regulators NF-YA and Sp1 Author(s): Allen KA, Williams AO, Isaacs RJ, et al. Source: ANTI-CANCER DRUGS Volume: 15 Issue: 4 Pages: 357-362 Published: APR 2004
- 2004, Health risks of herbal remedies: An update Author(s): De Smet PAGM Source: CLINICAL PHARMACOLOGY & THERAPEUTICS Volume: 76 Issue: 1 Pages: 1-17 Published: JUL 2004
- 2003, The transcriptional repressor protein PRH interacts with the proteasome Author(s): Bess KL, Swingler TE, Rivett AJ, et al.Source: BIOCHEMICAL JOURNAL Volume: 374 Pages: 667-675 Part: Part 3 Published: SEP 14 2003
- 2003, The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of elF4E-dependent cyclin D1 mRNA transport and growth Author(s): Topisirovic I, Culjkovic B, Cohen N, et al.Source: EMBO JOURNAL Volume: 22 Issue: 3 Pages: 689-703 Published: FEB 3 2003
- 2003, Witzmann FA, Grant RA Pharmacoproteomics in drug development PHARMACOGENOMICS JOURNAL 3 2 69-76 2003
- 2003, Naylor S, Kumar R Emerging role of mass spectrometry in structural and functional proteomics PROTEOME CHARACTERIZATION AND PROTEOMICS 65 217-248 2003
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- 2003, Analysis of protein tyrosine kinase inhibitors in recombinant yeast lacking the ERG6 gene Author(s): Clark DD, Peterson BR Source: CHEMBIOCHEM Volume: 4 Issue: 1 Pages: 101-107 Published: JAN 3 2003
- 2003, Camptothecin and 9-nitrocamptothecin (9NC) as anti-cancer, anti-HIV and cell-differentiation agents. Development of resistance, enhancement of 9NC-induced activities and combination treatments in cell and animal models Author(s): Pantazis P, Han ZY, Balan K, et al. Source: ANTICANCER RESEARCH Volume: 23 Issue: 5A Pages: 3623-3638 Published: SEP-OCT 2003
- 2003, Structural basis for topoisomerase I inhibition by nucleoside analogs Author(s): Gmeiner WH, Yu SY, Pon RT, et al. Source: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS Volume: 22 Issue: 5-8 Pages: 653-658 Published: 2003
- 2003, Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities Author(s): Wang BN, Perchellet EM, Wang Y, et al. Source: ANTI-CANCER DRUGS Volume: 14 Issue: 7 Pages: 503-514 Published: AUG 2003
- 2003, Phase I study of cisplatin, irinotecan, and epirubicin administered every 3 weeks in patients with advanced solid tumours Author(s): Chen X, Oza AM, Kusenda Z, et al. Source: BRITISH JOURNAL OF CANCER Volume: 89 Issue: 4 Pages: 617-624 Published: AUG 18 2003
- 2003, Unusual intercalation of acridin-9-ylthiourea into the 5 '-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate Author(s): Baruah H, Bierbach U Source: NUCLEIC ACIDS RESEARCH Volume: 31 Issue: 14 Pages: 4138-4146 Published: JUL 15 2003
- 2003, Development and use of a high-throughput bacterial DNA gyrase assay to identify mammalian topoisomerase II inhibitors with whole-cell anticancer activity Author(s): Roychoudhury S, Makin KM, Twinem TL, et al. Source: JOURNAL OF BIOMOLECULAR SCREENING Volume: 8 Issue: 2 Pages: 157-163 Published: APR 2003
- 2003, Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice Author(s): Takeuchi H, Saoo K, Yokohira M, et al. Source: CANCER RESEARCH Volume: 63 Issue: 22 Pages: 7581-7583 Published: NOV 15 2003
- 2003, Susceptibility and biomarker knowledge for improvement of environmental health Author(s): Salama SA, Au WW Source: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH Volume: 206 Issue: 4-5 Pages: 401-412 Published: AUG 2003
- 2003, Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men Author(s): Znaor A, Brennan P, Gajalakshmi V, et al. Source: INTERNATIONAL JOURNAL OF CANCER Volume: 105 Issue: 5 Pages: 681-686 Published: JUL 10 2003
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- 2003, Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis Author(s): Topisirovic I, Guzman ML, McConnell MJ, et al. Source: MOLECULAR AND CELLULAR BIOLOGY Volume: 23 Issue: 24 Pages: 8992-9002 Published: DEC 2003
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Tamamlanmış Araştırma Projeleri (10 adet)- 2013, TUBITAK (1001 nolu Proje) 112S492, Kemoterapi uygulamalarında hedeflenen insan topoizomeraz II enziminin moleküler etkileşimlerinin belirlenmesi ve protein partnerlerinin farmasötik önemlerinin değerlendirilmesi - Proje yürütücüsü
- 2009, TUBiTAK (1001 Nolu Proje) TBAG108T945, ADA3 proteininin transkripsiyonel regülasyondaki rolü ve diğer transkripsiyonel aktivatörlerle etkileşimleri - Proje yürütücüsü
- 2008, TUBİTAK (1001 Nolu Proje) TBAG108T548, DNA topoizomeraz enzimlerini hedefleyen potansiyel antikanser yapıların biyomoleküler etkileşimlerinin ayrımsal tanımlanması - Proje yürütücüsü
- 2007, Tübitak projesi, TBAG-2791, Recombinational telomere maintenance in K. lactis.
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- 2005, Araştırma Projesi, TUBİTAK SBAG-2791 (104S062)” nolu “Mutant telomerik tekrarlarla transforme edilen K.lactis hücrelerinde telomer devamlılığı Proje yürütücüsü.
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- 1998, Araştırma Projesi, TÜBİTAK TBAG-1865 Maya ikili hibrit sisteminde farmasötik uygulamaları. Proje yürütücüsü
- 1997, Araştırma Projesi, DPT 97K120890 Laboratuarımızda geliştirilen potansiyel anti-tümör kimyasalların memeli mitokondri DNA topoizomeraz enzimleri ile etkileşimlerinin belirlenmesi Proje Kodu: DPT Proje yürütücüsü.
- 1997, Araştırma Projesi, Medical Research Council of Canada. MT-13608. 'Investigation of the physiological partners of promyelocytic leukemia protein via yeast two hybrid methodology' Araştırmacı.
Bilimsel Kuruluş Üyeliklerim (5 adet)- European Association of Cancer research (EACR)
- International Society for Studying Xenobiotics
- International Society for Studying Xenobiotics
- Türk Biyokimya Derneği
- Türk Farmasötik Teknoloji Araştırma Derneği
Kazanılan Burslar (4 adet)- 2011, Fullbright Research Scholar
- 2004, Japanese Society of Pharmaceutical Research Fellowship
- 2001, Japanese Society of Pharmaceutical Research Fellowship
- 1997, European Molecular Biology Organization
Yöneterek Sonuçlandırdığı Öğrenci Tezleri (13 adet)- Yüksek Lisans, 2013, Temozolomid'in biyolojik aktivitesinin ayrımsal tanımlanması
- Doktora, 2012, ADA 3 proteininin transkripsiyonel regülasyondaki rolü ve diğer transkripsiyonel aktivatörlerle etkileşimleri
- Doktora, 2012, Bortezomib bileşiğinin DNA topoizomeraz enzimleri ile biyomoleküler etkileşimlerinin tanımlanması
- Yüksek Lisans, 2012, Koyunlarda sprn geni polimorfizminin incelenmesi
- Yüksek Lisans, 2012, Deneysel böbrek iskemi/reperfüzyon modelinde telomerik tekrar devamlılığı ve apoptoz ile bağlantısı
- Yüksek Lisans, 2010, Chlamyopsın-5 sensory rhodopsin protein ekspresyonunun ışığa bağlı değişiminin RT-PCR metodu ile belirlenmesi
- Yüksek Lisans, 2008, İnsan mide dokusunda CYP450 gen ekspresyonunun RT-PCR analizi
- Doktora, 2008, Tavşanlarda Balon Hasarı Sonrası Damar Düz Kas Hücrelerinde Telomer Devamlılığı ve Oksidan Stresinin Rolü 2. Danisman
- Yüksek Lisans, 2008, Mide antrum mukoza örneklerinde sitokrom P450 gen ekspresyonunun mRNA düzeyinde belirlenmesi
- Yüksek Lisans, 2007, Acc mutant telomerik tekrarlarla transforme kluveromyces lactis hücrelerinde telomer devamlılığının mekanizması
- Yüksek Lisans, 2006, K. lactis hücrelerinde telomerazdan bağımsız DNA telomer devamlılığı mekanizması
- Yüksek Lisans, 2005, CYP2A6 enzim ekspresyonu ve polimorfizmi
- Yüksek Lisans, 2005, Oral doku örneklerinde sitokrom P450 (CYP450) enzim ekspresyonunun belirlenmesi